国际生殖健康/计划生育杂志

国际生殖健康/计划生育 ›› 2020, Vol. 39 ›› Issue (4): 308-313.

• 综述 • 上一篇    下一篇

环状RNA在女性生殖系统中的研究进展 

张雪颖，应小燕，许波群   

  1. 210000  南京医科大学第二附属医院妇产科
  • 收稿日期:2020-02-08 修回日期:2020-03-16 出版日期:2020-07-15 发布日期:2020-07-15
  • 通讯作者: 许波群；E-mail：boqun_xu@njmu.edu.cn E-mail:boqun_xu@njmu.edu.cn
  • 基金资助:
    国家自然科学基金（81873820）；江苏省妇幼健康重点学科带头人（FXK201712）；南京医科大学重点项目（2017NJ
    MUZD033）

Research Progress in Circular RNA in Female Reproductive System

ZHANG Xue-ying，YING Xiao-yan，XU Bo-qun   

  1. Department of Obstetrics and Gynecology，The Second Affiliated Hospital of Nanjing Medical University，Nanjing 210000，China
  • Received:2020-02-08 Revised:2020-03-16 Published:2020-07-15 Online:2020-07-15
  • Contact: XU Bo-qun，E-mail：boqun_xu@njmu.edu.cn E-mail:boqun_xu@njmu.edu.cn

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摘要： 环状RNA（circRNA）是经反向剪接而成的一类共价闭合的环状非编码RNA，广泛存在于各种真核生物内，可通过结合RNA结合蛋白或海绵效应吸附微小RNA（miRNA）等机制发挥细胞信号传导、基因调控、蛋白质翻译等生物功能，参与各种生理和病理过程。研究发现，circRNA异常可能与女性生殖道肿瘤和女性内分泌相关疾病的发生、发展相关。其在女性生殖系统疾病中的潜在机制研究也逐渐深入。CircRNA保守、稳定、组织特异的生物学特性，使其有很大潜力作为女性生殖系统疾病诊断的生物标志物及治疗靶点。

关键词: RNA；, 微RNAs；, 泌尿生殖系统肿瘤；, 生殖器疾病, 女（雌）性；, 多囊卵巢综合征；, 先兆子痫

Abstract: Circular RNA (circRNA) is a large class of non-coding RNAs in eukaryotes which is bonded by the reverse splicing. Through binding with corresponding microRNAs or directly contacting with proteins, circRNA exerts the biological functions of cell signal transduction, gene regulation and protein translation, and plays a primarily important role in various physiological and pathological processes. Study found that the abnormality of circRNA could be related to the occurrence and development of female genital tract tumors and female endocrine-related diseases. The potential mechanism of circRNA in female reproductive system and diseases has also been gradually investigated. Owing to the biological characteristics of conservative, stability and tissue specificity, circRNA may be a class of potential diagnostic biomarkers and therapeutic targets of female reproductive system diseases.

Key words: RNA；, MicroRNAs；, Urogenital neoplasms；, Genital diseases, female；, Polycystic ovary syndrome；, Pre-eclampsia