铁过载及铁死亡对子宫内膜异位症患者生殖功能的影响

doi:10.12280/gjszjk.20230017

摘要/Abstract

摘要：

子宫内膜异位症是雌激素依赖性的慢性炎症性疾病，可能导致育龄期女性受精困难、卵母细胞质量下降、胚胎质量下降，从而导致不孕率的提高。尽管学者们普遍认为子宫内膜异位症与激素、炎症、氧化应激及遗传等因素有关，但其发病机制尚未完全阐明。最近铁过载及铁死亡在子宫内膜异位症中的研究备受关注。铁是包括人类在内的大多数生物体生存的基本要素，体内适当的铁水平可以促进胚胎的发育，缺铁容易引起生殖障碍。但有流行病学研究表明，摄入过量的铁或体内代谢后处于铁过载状态可能对女性生殖功能有害，铁过载会诱导铁死亡的发生。综述子宫内膜异位症中的铁过载及铁死亡对女性生殖系统不同方面的影响。

关键词: 子宫内膜异位症, 不育, 女（雌）性, 铁过载, 铁死亡, 泌尿生殖系统

Abstract:

Endometriosis as an estrogen-dependent chronic inflammatory disease may increase the rate of infertility in women of childbearing age by the decreased fertilization, poor oocyte quality and low quality of embryos. Although it is generally believed that endometriosis is related to hormonal, inflammatory, oxidative stress, genetic and other factors, the relevant mechanisms of endometriosis have not been fully clarified. Recently, iron overload and ferroptosis have been widely studied in endometriosis. Iron is a basic element for survival of most organisms including human beings, and iron deficiency may cause the disorder of reproduction. Adequate level of iron can promote embryonic development. However, the epidemiological studies have shown that excessive iron intake or high iron status may be harmful to female reproduction. Here, we focus on the impact of iron overload and ferroptosis in endometriosis on the different aspects of the female reproductive system.

Key words: Endometriosis, Infertility, female, Iron overload, Ferroptosis, Urogenital system

陈露, 杨春霞, 孙妍, 李峰, 薛同敏, 卢丹. 铁过载及铁死亡对子宫内膜异位症患者生殖功能的影响[J]. 国际生殖健康/计划生育杂志, 2023, 42(3): 261-264.

CHEN Lu, YANG Chun-xia, SUN Yan, LI Feng, XUE Tong-min, LU Dan. Effect of Iron Overload and Ferroptosis on the Reproductive Function of Endometriosis Patients[J]. Journal of International Reproductive Health/Family Planning, 2023, 42(3): 261-264.

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