miR-202在生殖调控中的研究进展

doi:10.12280/gjszjk.20240080

摘要/Abstract

摘要：

微小RNA（microRNA，miRNA）可调控细胞的增殖、分化、凋亡和代谢等生物过程，参与生物的生殖发育过程。作为let-7家族的一员，miR-202具有高度保守的碱基序列，提示miR-202在不同物种中的功能和调控作用可能相似。其可参与多种机体的病理生理过程，如减缓肿瘤细胞的增殖、迁移和侵袭，调控T细胞分化，参与调控神经发育和神经退行性疾病。还可参与配子的发生与成熟，调控生殖生理过程。综述miR-202在精子发生、卵泡发育及生殖内分泌中的调控作用。

关键词: 微RNAs, 精子发生, 性分化, 生殖细胞, 微小RNA-202, 生殖调控

Abstract:

MicroRNAs (miRNAs) have emerged as key regulators of diverse biological processes, including cell proliferation, differentiation, apoptosis, and metabolism. They are also actively involved in the reproductive and developmental processes of organisms. Among the let-7 family, miR-202 stands out owing to its high conservation across different species, implying the potential shared functions and regulatory roles. Substantial evidence from numerous studies underscores the involvement of miR-202 in a wide range of pathophysiological processes. Notably, it exerts significant inhibitory effects on tumor cell proliferation, migration, and invasion. Moreover, miR-202 plays a critical role in modulating the differentiation of T cell and exhibits the implications in the regulation of neurodevelopment and neurodegenerative diseases. The increasing evidence have indicated that miR-202 plays a crucial role in gamete development and the regulation of reproductive physiology. In this article, we review the regulatory roles of miR-202 in key reproductive processes, namely spermatogenesis, follicle development, and reproductive endocrine regulation.

Key words: MicroRNAs, Spermatogenesis, Sex differentiation, Germ cells, miR-202, Reproductive modulation

梁越, 董杰, 肖西峰, 王晓红. miR-202在生殖调控中的研究进展[J]. 国际生殖健康/计划生育杂志, 2024, 43(3): 228-233.

LIANG Yue, DONG Jie, XIAO Xi-feng, WANG Xiao-hong. Advancements of MiR-202 in Reproductive Modulation[J]. Journal of International Reproductive Health/Family Planning, 2024, 43(3): 228-233.

图/表 1

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物种	miRNA名称	碱基序列	碱基长度（bp）	miRBase Acession number*
人	hsa-miR-202-3p	AGAGGUAUAGGGCAUGGGAA	20	MIMAT0002811
	hsa-miR-202-5p	UUCCUAUGCAUAUACUUCUUUG	22	MIMAT0002810
小鼠	mmu-miR-202-3p	AGAGGUAUAGCGCAUGGGAAGA	22	MIMAT0000235
	mmu-miR-202-5p	UUCCUAUGCAUAUACUUCUUU	21	MIMAT0004546
牛	bta-miR-202	UUCCUAUGCAUAUACUUCUUU	21	MIMAT0009259
斑马鱼	dre-miR-202-3p	AGAGGCAUAGGGCAUGGGAAAA	22	MIMAT0001864
	dre-miR-202-5p	UUCCUAUGCAUAUACCUCUUUG	22	MIMAT0003406
红原鸡	gga-miR-202-3p	AGAGGCAUAGAGCAUGGGAAAA	22	MIMAT0003355
	gga-miR-202-5p	UUUCCUAUGCAUAUACUUCUUU	22	MIMAT0003354

物种	miRNA名称	碱基序列	碱基长度（bp）	miRBase Acession number*
人	hsa-miR-202-3p	AGAGGUAUAGGGCAUGGGAA	20	MIMAT0002811
	hsa-miR-202-5p	UUCCUAUGCAUAUACUUCUUUG	22	MIMAT0002810
小鼠	mmu-miR-202-3p	AGAGGUAUAGCGCAUGGGAAGA	22	MIMAT0000235
	mmu-miR-202-5p	UUCCUAUGCAUAUACUUCUUU	21	MIMAT0004546
牛	bta-miR-202	UUCCUAUGCAUAUACUUCUUU	21	MIMAT0009259
斑马鱼	dre-miR-202-3p	AGAGGCAUAGGGCAUGGGAAAA	22	MIMAT0001864
	dre-miR-202-5p	UUCCUAUGCAUAUACCUCUUUG	22	MIMAT0003406
红原鸡	gga-miR-202-3p	AGAGGCAUAGAGCAUGGGAAAA	22	MIMAT0003355
	gga-miR-202-5p	UUUCCUAUGCAUAUACUUCUUU	22	MIMAT0003354