Journal of International Reproductive Health/Family Planning

Journal of International Reproductive Health/Family Planning ›› 2010, Vol. 29 ›› Issue (4): 288-291.

• 综述 • Previous Articles     Next Articles

The Progress in the Insulin Resistance and Defects in Insulin Signaling Pathways in Women with Polycystic Ovary Syndrome

ZHANG Yan-fang, HAN Yu-kun   

  1. Department of Obstetrics and Gynecology,General Hospital of Tianjin Medical University, Tianjin 300052, China
  • Received:1900-01-01 Revised:1900-01-01 Published:2010-07-15 Online:2010-07-15
  • Contact: HAN Yu-kun

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Abstract: PI3K/AKT、MAPK/ERK cascades were two main cell signaling pathways of insulin effects,
which served to regulate cell metabolism, survival and apoptosis. It was autospecific that the states of these two
pathways in polycystic ovary syndrome（PCOS）patients, which meaned defects in insulin signaling pathways
and insulin resistance.There were lots of theories about insulin resistance in women with PCOS, including that
insulin resistance in PCOS women metained pathway鄄selective, tissue-specific, intrinsic and（or）acquired and
some special tissue remained insulin-sensitive despite the insulin-resistance in serum. The conditions of PI3K/
AKT and MAPK/ERK pathways in organs of PCOS patients differed from each other.

Key words: Polycystic ovary syndrome, Insulin resistance, Extracellular signal-regulated MAP kinases, 1-Phosphatidylinositol 3-kinase, Protein kinases