Abstract: The etiology of recurrent spontaneous abortion(RSA) is very complicated. The prethrombotic state related to RSA is hotspot research in recent years. More and more research indicated that the pathogenic factor of RSA could include the coagulation factor V mutation, prothrombin gene polymorphism, MTFHR gene mutation, protein C deficiency, protein S defect, fibrinogen gene mutation, anti-phospholipid syndrome antibody, angiotensin converting enzyme gene insertion and deletion, and PAI-1 gene polymorphism. There is no sufficient evidence that low-molecular-weight heparin can improve pregnancy outcome in RSA the patients with prethrombotic state. Medical researchers still actively explore the therapeutic regimen of RSA the prethrombotic state related to RSA, and put forward some useful treatment suggestions based on their experience in treatment of RSA and in assisted reproductive technology.

Key words: Abortion, habitual, Thrombosis, Biological markers, Prethrombotic state