国际生殖健康/计划生育杂志

国际生殖健康/计划生育 ›› 2013, Vol. 32 ›› Issue (3): 207-210.

• 综述 • 上一篇    下一篇

精子活动力与线粒体代谢的研究进展

凡 永,丁之德   

  1. 200025 上海交通大学医学院组织胚胎学教研室
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2013-05-15 发布日期:2013-05-15
  • 通讯作者: 丁之德

Mitochondrial Metabolism and Sperm Motility

FAN Yong, DING Zhi-de   

  1. Department of Histology and Embryology，School of Medicine，Shanghai Jiao Tong University，Shanghai 200025，China
  • Received:1900-01-01 Revised:1900-01-01 Published:2013-05-15 Online:2013-05-15
  • Contact: DING Zhi-de

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摘要： 弱精子症或精子无力症是一种由于精子活动力缺陷所引起的男性不育，约占男性不育症的19%，已成为男性不育的主要诱因之一。精子运动所需能量基本来自其线粒体呼吸链的氧化磷酸化，而任何与线粒体代谢相关的因素，如氧化应激、细胞凋亡及Ca2+循环等均可对精子活动力产生影响。综述近年来对精子活动力与其线粒体代谢的相关性及机制研究的进展。

关键词: 精子能动性, 线粒体, 氧化性应激, 细胞凋亡, Ca2+循环

Abstract: Asthenospermia is one kind of male infertility, about 19% in total cases, which caused by defects in sperm motility. Generally, the energy for sperm motility fundamentally comes from the oxidative phosphorylation of mitochondrial respiratory chain. Thus, any factors related mitochondrial metabolism, such as oxidative stress, cell apoptosis as well as Ca2+ cycle, will have significant influences on sperm motility. Herein, we reviewed the research advances on mitochondrial metabolism and sperm motility.

Key words: Sperm motility, Mitochondria, Oxidative stress, Apoptosis, Ca2+cycle