国际生殖健康/计划生育杂志

国际生殖健康/计划生育 ›› 2013, Vol. 32 ›› Issue (5): 400-404.

• 综述 • 上一篇    下一篇

肥胖对生殖影响的研究进展

沈 蕾, 丁之德   

  1. 200025 上海交通大学医学院营养系（沈 蕾）；上海交通大学医学院人体解剖与组织胚胎学系（丁之德）
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2013-09-15 发布日期:2013-09-15

Effects of Obesity on Reproduction

SHEN Lei，DING Zhi-de   

  1. Department of Nutrition，School of Medicine，Shanghai Jiao Tong University，Shanghai 200025，China（SHEN Lei）；Department of Human Anatomy，Histology and Embryology，School of Medicine，Shanghai Jiao Tong University，Shanghai 200025，China（DING Zhi-de）
  • Received:1900-01-01 Revised:1900-01-01 Published:2013-09-15 Online:2013-09-15

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摘要： 肥胖症的发病率在过去10年中几乎增加了1倍，而肥胖及其并发症所带来的直接或间接耗费约占国家卫生经费的10%。除心血管疾病等并发症外，近年来越来越多的研究结果发现，肥胖对男性、女性及雄、雌性实验鼠的生殖系统均有明显的负面效应。如肥胖可增加男性患前列腺癌的风险，并可引起性功能和精液质量的下降；对女性而言，肥胖可增加患多囊卵巢综合征的风险、并可引起生育力和卵细胞质量的下降；此外，肥胖还对儿童青少年的生长发育带来极大的危害。综述肥胖对生殖内分泌代谢、生殖器官形态学、性功能及生殖细胞发育等方面的影响。

关键词: 肥胖, 男（雄性）, 女（雌性）, 生殖

Abstract: The occurrence of obesity increased almost two folds in the last decade，meanwhile the expense exhausted directly or indirectly by obesity and its complications reached about 10% of the overall state′s health expenditures. Besides its cardiovascular complications, obesity has significant negative effects on the reproductive system of both men and women，which was confirmed by animal experiments in male and female rodents. Obesity is a risk factor of prostatic cancer，sexual dysfunction, and the declined sperm quality, in males. Obesity is a risk factor of PCOS in females, the declined oocytes quality, and lowered fertile ability. Moreover，obesity has some severe detriments on the growth and development of children and teenagers. In this review，we elucidated the effects of obesity on reproductive endocrinology and metabolism，morphology of reproductive organs，sexual ability，and development of reproductive cells.

Key words: Obesity, Male, Female, Reproduction