国际生殖健康/计划生育杂志

国际生殖健康/计划生育 ›› 2015, Vol. 34 ›› Issue (4): 273-277.

• 论著 • 上一篇    下一篇

辅助生殖技术出生的学龄前儿童血微量元素水平的研究

柴德春，张园，胡幼芳，李婧，秦瑞，高莉，崔毓桂，刘嘉茵   

  1. 210029 南京医科大学第一附属医院生殖医学科（柴德春，张园，高莉，崔毓桂，刘嘉茵）；儿保科（胡幼芳，李婧，秦瑞）
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2015-07-15 发布日期:2015-07-15
  • 通讯作者: 崔毓桂

Analysis of Blood Traceelements in Preschool Children Born from Assisted Reproductive Technology

CHAI De-chun，ZHANG Yuan，HU You-fang，LI Jing，QIN Rui，GAO Li，CUI Yu-gui，LIU Jia-yin   

  1. Clinical Center of Reproductive Medicine （CHAI De-chun，ZHANG Yuan，GAO Li，CUI Yu-gui，LIU Jia-yin），Department of Child Health（HU You-fang，LI Jing，QIN Rui），The First Affiliated Hospital of Nanjing Medical University，Nanjing 210029，China
  • Received:1900-01-01 Revised:1900-01-01 Published:2015-07-15 Online:2015-07-15
  • Contact: CUI Yu-gui

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摘要： 目的：以小样本分析探讨江苏省辅助生殖技术（ART）出生的学龄前儿童血微量元素水平。方法：以江苏省63例ART出生的学龄前儿童（3～6岁）为ART组，对照组为37例自然妊娠出生的学龄前儿童（3～6岁）。均无染色体异常，无肥胖和其他代谢疾病，体检发育指标均正常。利用BH5100型多通道原子吸收光谱仪和BH2100型金属炉原子吸收光谱仪测定末梢全血锌、铜、铁、钙、镁、铅等微量元素的含量。结果：63例ART子代的儿童身体发育指标与对照组儿童差别无统计学意义。ART组学龄前儿童的末梢全血微量元素的平均水平均在正常范围。ART组学龄前儿童血锌含量平均值低于对照组；3～5岁血铅水平高于对照组（均P＜0.01）。结论：ART出生的学龄前儿童血微量元素平均水平在正常范围内，提示ART是安全的。ART出生的学龄前儿童血锌水平略低、3～5岁血铅水平略高于正常妊娠的儿童，需要进行扩大样本量的研究和进一步追踪随访。

关键词: 生殖技术, 辅助, 儿童, 学龄前, 儿童发育, 微量元素, 血铅

Abstract: Objective: To analyze the levels of blood traceelements in those preschool children born from assisted reproductive technology （ＡＲＴ）, and to evaluate the developmental status, when compared with those children from natural pregnancy. Methods：Totally, 63 preschool children of ART aged 3 to 6 years （ＡＲＴ ｇｒｏｕｐ）, and 37 children of the same age and from natural pregnancy （ｃｏｎｔｒｏｌ ｇｒｏｕｐ）, from Jiangsu Province were included in this study. Those children with chromosome abnormity, overweight or obesity or other metabolic disorders, had been excluded. Levels of serum zinc, copper, ferrum, calcium, magnesium and lead were analyzed using the BH5100 and BH2100 atomic absorption spectrum instrument and meters. Results：There were not significant differences in body weight, height, bone age, serum biochemistry parameters between two groups. The mean levels of all traceelements in the ART children were in the normal ranges of the same age children. The mean level of zinc in the ART group was slightly lower, and the level of lead higher （P＜０．０1）, than those in the control group. Conclusions：The mean levels of blood traceelements in those preschool children born from ART are within the normal ranges, which suggested the ART safety in the absorption and metabolism of traceelements. It is necessary to study further in the large sample, and to track, whether the levels of zinc and lead are authentically discrepant in those ART children.

Key words: Reproductive techniques, assisted, Child, preschoo, Child development, Traceelements, Serum lead