Abstract: Objective： To investigate whether the embryonic stem cells（ＥＳＣ） could selective implant into the uterine cavities of endometrium-injured mouse and help the endometrium reparation. Methods：The mouse model with freshly injured endometrium was established. ESCs derived from EGFP transgenic mouse were transplanted into the endometrium-injured mouse uterines. Then, the retention and the effects of ESCs on the reparation of injured endometrium and the tumorigenicity of post-transplanted stem cells were observed. Results：The ESCs survived in the uterine cavities more than 3 weeks with the rate of tumorigenicity increasing in time dependently. ESCs intravenous-injected could concentrated in the endometrium-injured uterine cavities and other injured parts of the body. Conclusions：Injury is the most important inducing factor of ESCs recruitment. However，the problems of inducing directional differentiation and managing the neoplasia of ESCs are remain unsolved.

Key words: Embryonic stem cells, Endometrium, Transplantation, Green fluorescent proteins, Teratoma