Abstract: Objective：To assess the long-term effect of gestational hypertension and pre-eclampsia on the renal function. Methods: Retrospective study were designed in those primipara, including 3 583 cases of gestational hypertension (GH group), 811 cases of pre-eclampsia (PE group) and 10 457 cases of normotensive (the control group), from January 2013 to August 2015. The occurrence rates of chronic kidney disease (CKD) and hospital admission related to kidney diseases within two years of follow-up visit were compared. Results: The rates of CKD in the PE group, GH group and the control group were 7.5% (61/811), 5.2% (188/3 583) and 3.9% (405/10 457), respectively. The unadjusted odds ratios (95% confidence interval) of CKD were 2.02 (95%CI: 1.53~2.67) in the PE group and 1.37 (95%CI: 1.15-1.64) in the GH group. This ratio was then adjusted for age and year at delivery, BMI, degree of education and smoking status in present study. The adjusted odds ratios were 1.92 (95%CI: 1.45-2.56) and 1.36 (95%CI: 1.14-1.63) in two groups. Logistic regression analysis showed that the risk ratio of CKD in the PE group was higher than that in the GH group. The risk ratios of CKD and the rates of renal disease admission in the PE group and GH group were higher than those in the control group. Conclusions: The risk of CKD was increased in those women undergone GH and PE, while CKD was diagnosed earlier.

Key words: Hypertension, pregnancy-induced, Pre-eclampsia, Chronic disease, Kidney diseases