Abstract: Wnt singaling path ways play important role in various processes such as fetal development tumorigenesis and homeostasis. Wnt signaling related genes exhibit spatiotemporal expression in the uterus during mouse peri-implantation and that they are tightly regulated by critical implantation-related genes, such
as LIF and HOXA-10. Wnt/beta-catenin signaling, which has been proven to participate in tumorigenesis and early embryo development. Dkk（Dickkopf）family plays an critical role in embryo implantation by mediating Wnt signaling and induce the change in endometrial receptivity in space-time specificitily. Wnt signaling and Dkk are very critical factor in endometrium during the peri-implantation period.

Key words: Dkk protein, Wnt, Endometrial receptivity, Embryo implantation